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Invokana. A Diabetes Drug That CAN KILL YOU.

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Invokana Lawsuit – Kidney & Heart Damage

 

 

Invokana is a SGLT2 inhibitor used in combination with diet and exercise to lower blood sugar and improve glycemic control in adults with type 2 diabetes. When untreated, type 2 diabetes can lead to serious problems, including blindness, nerve damage, kidney failure, heart disease, stroke, high blood pressure, and a range of other problems. Diabetes is the seventh leading cause of death in the United States. SGLT2 inhibitors lower a person’s blood sugar by causing the kidneys to remove the sugar through the urine.

Invokana Side Effects

The most serious potential side effects, problems and risks caused through the use Invokana are myocardial infarction (heart attack), kidney damage and ketoacidosis.

If you are currently taking Invokana or another SGLT2 inhibitor (such as Invokamet, Farxiga, Xigduo XR, Jardiance or Glyxambia), you should pay close attention for any signs of kidney failure, heart problems and acidosis and seek immediate medical attention if you experience symptoms such as chest pain, dizziness, faintness, increased heart rate, increased pulmonary rate, difficulty breathing, hyperventilation, weakness, changes in urination, anorexia, nausea, vomiting, abdominal pain, confusion, and unusual fatigue or sleepiness. Do not stop or change your diabetes medication without first talking to your medical provider, but be especially careful to take appropriate measures to monitor for signs of kidney issues, heart problems, and acidosis, and immediately seek appropriate medical care if you have any concerns.

Before taking Invokana, or if you presently are taking Invokana, make sure to tell your doctor if any of the following factors apply to you, as they increase your likelihood of having medical problems by taking Invokana: (1) kidney disease; (2) liver disease; (3) heart disease; (4) high blood pressure; (5) low blood pressure; (6) an electrolyte imbalance (such as high levels of potassium in your blood); (7) high cholesterol; (8) if you are on a low-salt diet; or (9) if you use insulin or other diabetes medicine. It is unknown whether Invokana can harm a fetus or an infant being breastfed. Make sure to talk to your doctor if you plan to become pregnant, are pregnant, or are breastfeeding.

Diabetes Drug Invokana Linked to Ketoacidosis and Potential Kidney and Heart Failure

Published on Aug 27, 2016

A blockbuster diabetes drug called Invokana has pulled in hundreds of millions of dollars for Big Pharma, but the FDA recently announced that the treatment is causing even more problems in diabetics. Ring of Fire’s Mike Papantonio discusses this with attorney Tim O’Brien.

Diabetic ketoacidosis

SGLT-2 inhibitor drugs act by blocking the reabsorption of sugar in the kidneys, actually leading to a massive excretion of glucose in the urine. Since the body has no more sugar available to produce energy, it starts consuming fats from the adipose tissue, producing byproducts called ketone bodies. When the level of these waste products increases too much, the blood becomes acidic causing a life-threatening condition called diabetic ketoacidosis (DKA) that requires immediate hospitalization. In December 2015, the U.S. Food and Drug Administration (FDA) revised the label of all drugs in this class to warn all patients about this serious side effect.

Symptoms of diabetic ketoacidosis (DKA)

  • Abdominal pain
  • Coma
  • Difficulties breathing
  • Frequent urination
  • Fruity-smelling breath
  • Muscles aching
  • Nausea and vomiting
  • Tiredness and weakness
  • Unusual thirst

Urinary tract infections and kidney failure

Invokana’s mechanism of action increases the elimination of glucose in urine. However, a higher sugar concentration also provides a more suitable environment for many bacteria and yeasts to reproduce and thrive. In December 2015, the FDA required an additional warning on the drug’s label about an increased risk of urinary tract infections (UTIs) as well as yeast infections especially in women and seniors. Some of these infections were so severe that patients later suffered serious renal complications (urosepsis and pyelonephritis). Especially on patients with pre-existing kidney problems, canagliflozin can increase the risk of kidney failure.

The Institute for Safe Medication Practices (ISMP) also has warned about additional adverse reactions suffered by patients under treatment with this drug. Those complications include kidney failure, kidney stones, dehydration and fluid imbalances. Patients also have shown signs of reduced renal function (glomerular filtration rates – eGFR), and higher rates of fungal infections.

Diabetes Drug Invokana: The Treatment Might Be Worse than the Disease

Published on Jun 10, 2016

Type 2 diabetes is one of the fastest growing epidemics in America, and as a result, big pharma companies are hoping to make it their latest cash cow. But one of the most popular diabetes drugs on the market has been found to have some deadly side effects. Ring of Fire’s Farron Cousins and attorney David Haynes discuss those side effects.

To learn more about the Invokana litigation, visit https://www.levinlaw.com/invokana-law… and http://drugsafetynews.com/invokana/

Heart attacks and strokes

After the FDA required Johnson & Johnson to perform a larger post-marketing study to assess the medication’s safety in real-world environments, an additional side effect emerged. According to the data shown on the CANVAS trial, canagliflozin was linked with a significantly higher rate of cardiovascular accidents and strokes during the first 30 days of treatment. The drug effects can increase the risk of blood clots as well as produce negative changes in cholesterol levels, resulting in heart attacks and cerebral ischemia.

Bone fractures

On September 2015, the FDA modified the drug’s label to warn patients about a possible risk of bone fractures. Clinical studies showed an increased occurrence of fractures as early as 12 weeks after treatment initiation. The drug has also been linked to decreases in bone mineral density at the hip and lumbar spine, causing the bones to break even after a minor trauma is sustained.

Is Invokana safe during pregnancy

This medication has been classified by the FDA as pregnancy risk category of C. Although no human tests are available to assess its risks, in rat fetuses this drug damaged kidney development. Traces of this drug were found in the milk of lactating rats, meaning that breastfeeding mothers should talk to their doctors before taking it.

FDA and Scientific Studies Regarding Invokana

FDA Drug Safety Communication: FDA revises labels of SGLT2 inhibitors [such as Invokana] for diabetes to include warnings about too much acid in the blood and serious urinary tract infections

Patients should stop taking their SGLT2 inhibitor [such as Invokana] and seek medical attention immediately if they have any symptoms of ketoacidosis, a serious condition in which the body produces high levels of blood acids called ketones. Symptoms of ketoacidosis include nausea, vomiting, abdominal pain, tiredness, and trouble breathing. Patients should also be alert for signs and symptoms of a urinary tract infection, such as a feeling of burning when urinating or the need to urinate often or right away; pain in the lower part of the stomach area or pelvis; fever; or blood in the urine. Contact a health care professional if you experience any of these symptoms. To read more, click FDA Drug Safety

invokana-diabetes-lawyer

FDA Drug Safety Communication: FDA warns that SGLT2 inhibitors for diabetes may result in a serious condition of too much acid in the blood

The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines canagliflozin, dapagliflozin, and empagliflozin may lead to ketoacidosis, a serious condition where the body produces high levels of blood acids called ketones that may require hospitalization. We are continuing to investigate this safety issue and will determine whether changes are needed in the prescribing information for this class of drugs, called sodium-glucose cotransporter-2 (SGLT2) inhibitors. To read more, click FDA Drug Safety

Invokana Recall Information

As of this time, there has not been a recall of Invokana related to kidney failure, myocardial infarction or ketoacidosis. However, the U.S. Food and Drug Administration has issued two safety announcements warning patients to stop taking Invokana, and seek immediate medical help, if they suffer any symptoms of ketoacidosis, such as nausea, vomiting, abdominal pain, tiredness, or trouble breathing.

No recall, but FDA has issued two warnings regarding the link to ketoacidosis

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